Research Publications

Research Articles in Peer Reviewed Publications

Timothy M. Buie, MD   Boston Children’s Hospital Attending Physician, Division of Gastroenterology, Hepatology and Nutrition Assistant Professor of Pediatrics, Harvard Medical School

  1. Ballal, Sonia A.; Greenwell, Saige; Liu, Enju; Buie, Timothy; Silvester, Jocelyn; Leier, McKenzie; Filippelli, Maura; Bousvaros, Athos; Hron, Bridget. Comparing Gastrointestinal Endoscopy Findings in Children with Autism, Developmental Delay or Typical Development. Journal of Pediatrics, September 15, 2023 View abstract 
  2. Rodriguez, Leonel; Morley-Fletcher, Alessio; Winter, Harland; Buie, Timothy. Evaluation of Gastroesophageal Reflux Disease in Children on the Autism Spectrum: A Study Evaluating the Tolerance and Utility of the BRAVO Wireless pH Monitoring. Journal of Pediatric Gastroenterology and Nutrition: October 2022 - Volume 75 - Issue 4 - p 450-454.View abstract
  3. Calliope Holingue, Luther G. Kalb, Rashelle Musci, Colleen Lukens, Li-Ching Lee, Jamie Kaczaniuk, Michelle Landrum, Timothy Buie, M. Daniele Fallin; Characteristics of the autism Spectrum Disorder Gastrointestinal and Related Behaviors Inventory in Children. This article may be accessed on the publisher’s (Wiley) website. Here's the link to Autism Research open source (ASD-GIRBI) paper. First published: 18 March 2022: [https://doi.org/10.1002/aur.2707]
  4. Margolis KG, Buie TM, Turner JB, Silberman AE, Feldman JF, Murray KF, McSwiggan-Hardin M, Levy J, Bauman ML, Veenstra-VanderWeele J, Whitaker AH, Winter HS. Development of a Brief Parent-Report Screen for Common Gastrointestinal Disorders in Autism Spectrum Disorder. J Autism Dev Disord. 2019 Jan; 49(1):349-362. View abstract.
  5. Walsh EC, Lee JM, Terzakis K, Zhou DW, Burns S, Buie TM, Firth PG, Shank ES, Houle TT, Brown EN, Purdon PL. Age-Dependent Changes in the Propofol-Induced Electroencephalogram in Children With Autism Spectrum Disorder. Front Syst Neurosci. 2018; 12:23. View abstract
  6. Rose S, Bennuri SC, Murray KF, Buie T, Winter H, Frye RE. Mitochondrial dysfunction in the gastrointestinal mucosa of children with autism: A blinded case-control study. PLoS One. 2017; 12(10):e0186377. View abstract
  7. Kushak RI, Winter HS, Buie TM, Cox SB, Phillips CD, Ward NL. Analysis of the Duodenal Microbiome in Autistic Individuals: Association With Carbohydrate Digestion. J Pediatr Gastroenterol Nutr. 2017 05; 64(5):e110-e116. View abstract
  8. Fiorentino M, Sapone A, Senger S, Camhi SS, Kadzielski SM, Buie TM, Kelly DL, Cascella N, Fasano A. Blood-brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders. Mol Autism. 2016; 7:49. View abstract
  9. Kushak RI, Buie TM, Murray KF, Newburg DS, Chen C, Nestoridi E, Winter HS. Evaluation of Intestinal Function in Children With Autism and Gastrointestinal Symptoms. J Pediatr Gastroenterol Nutr. 2016 05; 62(5):687-91. View abstract
  10. Zwaigenbaum L, Bauman ML, Stone WL, Yirmiya N, Estes A, Hansen RL, McPartland JC, Natowicz MR, Choueiri R, Fein D, Kasari C, Pierce K, Buie T, Carter A, Davis PA, Granpeesheh D, Mailloux Z, Newschaffer C, Robins D, Roley SS, Wagner S, Wetherby A. Early Identification of Autism Spectrum Disorder: Recommendations for Practice and Research. Pediatrics. 2015 Oct; 136 Suppl 1:S10-40. View abstract
  11. Zwaigenbaum L, Bauman ML, Fein D, Pierce K, Buie T, Davis PA, Newschaffer C, Robins DL, Wetherby A, Choueiri R, Kasari C, Stone WL, Yirmiya N, Estes A, Hansen RL, McPartland JC, Natowicz MR, Carter A, Granpeesheh D, Mailloux Z, Smith Roley S, Wagner S. Early Screening of Autism Spectrum Disorder: Recommendations for Practice and Research. Pediatrics. 2015 Oct; 136 Suppl 1:S41-59. View abstract
  12. Zwaigenbaum L, Bauman ML, Choueiri R, Fein D, Kasari C, Pierce K, Stone WL, Yirmiya N, Estes A, Hansen RL, McPartland JC, Natowicz MR, Buie T, Carter A, Davis PA, Granpeesheh D, Mailloux Z, Newschaffer C, Robins D, Smith Roley S, Wagner S, Wetherby A. Early Identification and Interventions for Autism Spectrum Disorder: Executive Summary. Pediatrics. 2015 Oct; 136 Suppl 1:S1-9. View abstract
  13. Zwaigenbaum L, Bauman ML, Choueiri R, Kasari C, Carter A, Granpeesheh D, Mailloux Z, Smith Roley S, Wagner S, Fein D, Pierce K, Buie T, Davis PA, Newschaffer C, Robins D, Wetherby A, Stone WL, Yirmiya N, Estes A, Hansen RL, McPartland JC, Natowicz MR. Early Intervention for Children With Autism Spectrum Disorder Under 3 Years of Age: Recommendations for Practice and Research. Pediatrics. 2015 Oct; 136 Suppl 1:S60-81. View abstract
  14. Buie T. Potential Etiologic Factors of Microbiome Disruption in Autism. Clin Ther. 2015 May 01; 37(5):976-83. View abstract]Buie T. The relationship of autism and gluten. Clin Ther. 2013 May; 35(5):578-83. View abstract
  1. Williams BL, Hornig M, Buie T, Bauman ML, Cho Paik M, Wick I, Bennett A, Jabado O, Hirschberg DL, Lipkin WI. Impaired carbohydrate digestion and transport and mucosal dysbiosis in the intestines of children with autism and gastrointestinal disturbances. PLoS One. 2011; 6(9):e24585. View abstract
  2. Kushak RI, Lauwers GY, Winter HS, Buie TM. Intestinal disaccharidase activity in patients with autism: effect of age, gender, and intestinal inflammation. Autism. 2011 May; 15(3):285-94. View abstract
  3. Buie T, Fuchs GJ, Furuta GT, Kooros K, Levy J, Lewis JD, Wershil BK, Winter H. Recommendations for evaluation and treatment of common gastrointestinal problems in children with ASDs. Pediatrics. 2010 Jan; 125 Suppl 1:S19-29. View abstract
  4. Buie T, Campbell DB, Fuchs GJ, Furuta GT, Levy J, Vandewater J, Whitaker AH, Atkins D, Bauman ML, Beaudet AL, Carr EG, Gershon MD, Hyman SL, Jirapinyo P, Jyonouchi H, Kooros K, Kushak R, Levitt P, Levy SE, Lewis JD, Murray KF, Natowicz MR, Sabra A, Wershil BK, Weston SC, Zeltzer L, Winter H. Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report. Pediatrics. 2010 Jan; 125 Suppl 1:S1-18. View abstract
  5. Campbell DB, Buie TM, Winter H, Bauman M, Sutcliffe JS, Perrin JM, Levitt P. Distinct genetic risk based on association of MET in families with co-occurring autism and gastrointestinal conditions. Pediatrics. 2009 Mar; 123(3):1018-24. View abstract
  6. Hornig M, Briese T, Buie T, Bauman ML, Lauwers G, Siemetzki U, Hummel K, Rota PA, Bellini WJ, O'Leary JJ, Sheils O, Alden E, Pickering L, Lipkin WI. Lack of association between measles virus vaccine and autism with enteropathy: a case-control study. PLoS One. 2008 Sep 04; 3(9):e3140. View abstract
  7. Nanthakumar NN, Young C, Ko JS, Meng D, Chen J, Buie T, Walker WA. Glucocorticoid responsiveness in developing human intestine: possible role in prevention of necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2005 Jan; 288(1):G85-92. View abstract
  8. Chitkara DK, Nurko S, Shoffner JM, Buie T, Flores A. Abnormalities in gastrointestinal motility are associated with diseases of oxidative phosphorylation in children. Am J Gastroenterol. 2003 Apr; 98(4):871-7. View abstract
  9. Biller JA, Katz AJ, Flores AF, Buie TM, Gorbach SL. Treatment of recurrent Clostridium difficile colitis with Lactobacillus GG. J Pediatr Gastroenterol Nutr. 1995 Aug; 21(2):224-6. View abstract
  10. Di Lorenzo C, Flores AF, Buie T, Hyman PE. Intestinal motility and jejunal feeding in children with chronic intestinal pseudo-obstruction. Gastroenterology. 1995 May; 108(5):1379-85. View abstract
  11. Gryboski JD, Buie T. Immunoglobulin studies in children with inflammatory bowel disease. Ann Allergy. 1994 Jun; 72(6):525-7. View abstract
  12. Irons M, Elias ER, Tint GS, Salen G, Frieden R, Buie TM, Ampola M. Abnormal cholesterol metabolism in the Smith-Lemli-Opitz syndrome: report of clinical and biochemical findings in four patients and treatment in one patient. Am J Med Genet. 1994 May 01; 50(4):347-52. View abstract
  13. Biller JA, Flores A, Buie T, Mazor S, Katz AJ. Tetracycline-induced esophagitis in adolescent patients. J Pediatr. 1992 Jan; 120(1):144-5. View abstract