About

PediGi
PediGi

Dr. Timothy Buie
Co-Director of the GI-Autism Clinic

Senior Physician and Pediatric Gastroenterologist, Boston Children’s Hospital,
Harvard Medical School

Timothy M. Buie, M.D. is the Co-Director of the GI Autism Clinic and a Senior Physician in the Pediatric Gastroenterology, Nutrition and Hepatology Department at Boston Children’s Hospital. Prior to that position, he worked in the pediatric gastroenterology department for 18 years at Massachusetts General Hospital for Children based in Boston, MA. He also served as the Director of Gastrointestinal and Nutrition at Massachusetts General Hospital’s Lurie Center for Autism. Dr. Buie is an Assistant Professor of Pediatrics at Harvard Medical School. He completed his training in Pediatric Gastroenterology at Yale University School of Medicine.

In addition to managing a large patient population, Dr. Buie has published a variety of papers and book chapters characterizing gastrointestinal problems in children with autism and developmental disorders including clinical presentation and medical findings. His work includes translational research of the intestinal microbiome and the metabolic effects of the microbiome in a variety of conditions in pediatrics including autism and inflammatory disease.

Dr. Buie has been featured in The New York Times, The Wall Street Journal on PBS, the BBC and media worldwide talking about gastrointestinal symptoms, diet and nutrition, and the microbiome differences seen in individuals with autism. He is currently featured on AutismSpeaks.org and YouTube in an online medical video series entitled “Office Hours with GI Specialist Tim Buie” that he developed and co-produced with Autism Speaks. He has also been a contributor to the advice column “Food for Thought” on the Autism Speaks website.

​Dr. Buie has been honored for his work in medicine over the years and in June 2021 was awarded 2019-2020 Attending of the Year by the Harvard Medical School Fellowship/Pediatric Gastroenterology and Nutrition Department at Boston Children’s Hospital. He is the recipient of the Margaret Bauman Award for Autism Care presented in May 2017, which he also received in 2010. He was named Professional of the Year by the Autism Society of America in 2010 and received the Partners in Excellence Award in 2014. Dr. Buie received the University of Missouri-Kansas City School of Medicine’s Take Wing Award in 2015 honoring his career achievements and professional excellence.

​Dr. Buie serves on the Interagency Coordinating Committee for Autism advisory board for the National Institutes of Health. He also serves on the Harvard Medical School TEAMS clinical advisory board (Targeted Education Autism for Management across Medical Specialties) aimed at teaching all Harvard clinical providers autism management strategies.

Please review the list of Dr. Buie’s publications below. To view his online profile on the Boston Children’s Hospital website:
www.childrenshospital.org/directory/physicians/b/timothy-buie

Boston Children’s Hospital is ranked the #1 in pediatric hospital in the world according to Newsweek.

Research Articles in Peer Reviewed Publications

Timothy M. Buie, MD   Boston Children’s Hospital Attending Physician, Division of Gastroenterology, Hepatology and Nutrition Assistant Professor of Pediatrics, Harvard Medical School

  1. Buie, Timothy; Margolis, Kara. Considerations for Treating Autistic Individuals in Gastroenterology Clinics. The Lancet Gastroenterology & Hepatology, Vo. 9 No. 8 p. 684-686 May 20, 2024 View Abstract
  2. Ballal, Sonia A.; Greenwell, Saige; Liu, Enju; Buie, Timothy; Silvester, Jocelyn; Leier, McKenzie; Filippelli, Maura; Bousvaros, Athos; Hron, Bridget. Comparing Gastrointestinal Endoscopy Findings in Children with Autism, Developmental Delay or Typical Development. Journal of Pediatrics, September 15, 2023 View abstract
  3. Rodriguez, Leonel; Morley-Fletcher, Alessio; Winter, Harland; Buie, Timothy. Evaluation of Gastroesophageal Reflux Disease in Children on the Autism Spectrum: A Study Evaluating the Tolerance and Utility of the BRAVO Wireless pH Monitoring. Journal of Pediatric Gastroenterology and Nutrition: October 2022 - Volume 75 - Issue 4 - p 450-454.View abstract
  4. Calliope Holingue, Luther G. Kalb, Rashelle Musci, Colleen Lukens, Li-Ching Lee, Jamie Kaczaniuk, Michelle Landrum, Timothy Buie, M. Daniele Fallin; Characteristics of the autism Spectrum Disorder Gastrointestinal and Related Behaviors Inventory in Children. This article may be accessed on the publisher’s (Wiley) website. Here's the link to Autism Research open source (ASD-GIRBI) paper. First published: 18 March 2022: https://doi.org/10.1002/aur.2707
  5. Margolis KG, Buie TM, Turner JB, Silberman AE, Feldman JF, Murray KF, McSwiggan-Hardin M, Levy J, Bauman ML, Veenstra-VanderWeele J, Whitaker AH, Winter HS. Development of a Brief Parent-Report Screen for Common Gastrointestinal Disorders in Autism Spectrum Disorder. J Autism Dev Disord. 2019 Jan; 49(1):349-362. View abstract.
  6. Walsh EC, Lee JM, Terzakis K, Zhou DW, Burns S, Buie TM, Firth PG, Shank ES, Houle TT, Brown EN, Purdon PL. Age-Dependent Changes in the Propofol-Induced Electroencephalogram in Children With Autism Spectrum Disorder. Front Syst Neurosci. 2018; 12:23. View abstract
  7. Rose S, Bennuri SC, Murray KF, Buie T, Winter H, Frye RE. Mitochondrial dysfunction in the gastrointestinal mucosa of children with autism: A blinded case-control study. PLoS One. 2017; 12(10):e0186377. View abstract
  8. Kushak RI, Winter HS, Buie TM, Cox SB, Phillips CD, Ward NL. Analysis of the Duodenal Microbiome in Autistic Individuals: Association With Carbohydrate Digestion. J Pediatr Gastroenterol Nutr. 2017 05; 64(5):e110-e116. View abstract
  9. Fiorentino M, Sapone A, Senger S, Camhi SS, Kadzielski SM, Buie TM, Kelly DL, Cascella N, Fasano A. Blood-brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders. Mol Autism. 2016; 7:49. View abstract
  10. Kushak RI, Buie TM, Murray KF, Newburg DS, Chen C, Nestoridi E, Winter HS. Evaluation of Intestinal Function in Children With Autism and Gastrointestinal Symptoms. J Pediatr Gastroenterol Nutr. 2016 05; 62(5):687-91. View abstract
  11. Zwaigenbaum L, Bauman ML, Stone WL, Yirmiya N, Estes A, Hansen RL, McPartland JC, Natowicz MR, Choueiri R, Fein D, Kasari C, Pierce K, Buie T, Carter A, Davis PA, Granpeesheh D, Mailloux Z, Newschaffer C, Robins D, Roley SS, Wagner S, Wetherby A. Early Identification of Autism Spectrum Disorder: Recommendations for Practice and Research. Pediatrics. 2015 Oct; 136 Suppl 1:S10-40. View abstract
  12. Zwaigenbaum L, Bauman ML, Fein D, Pierce K, Buie T, Davis PA, Newschaffer C, Robins DL, Wetherby A, Choueiri R, Kasari C, Stone WL, Yirmiya N, Estes A, Hansen RL, McPartland JC, Natowicz MR, Carter A, Granpeesheh D, Mailloux Z, Smith Roley S, Wagner S. Early Screening of Autism Spectrum Disorder: Recommendations for Practice and Research. Pediatrics. 2015 Oct; 136 Suppl 1:S41-59. View abstract
  13. Zwaigenbaum L, Bauman ML, Choueiri R, Fein D, Kasari C, Pierce K, Stone WL, Yirmiya N, Estes A, Hansen RL, McPartland JC, Natowicz MR, Buie T, Carter A, Davis PA, Granpeesheh D, Mailloux Z, Newschaffer C, Robins D, Smith Roley S, Wagner S, Wetherby A. Early Identification and Interventions for Autism Spectrum Disorder: Executive Summary. Pediatrics. 2015 Oct; 136 Suppl 1:S1-9. View abstract
  1. Zwaigenbaum L, Bauman ML, Choueiri R, Kasari C, Carter A, Granpeesheh D, Mailloux Z, Smith Roley S, Wagner S, Fein D, Pierce K, Buie T, Davis PA, Newschaffer C, Robins D, Wetherby A, Stone WL, Yirmiya N, Estes A, Hansen RL, McPartland JC, Natowicz MR. Early Intervention for Children With Autism Spectrum Disorder Under 3 Years of Age: Recommendations for Practice and Research. Pediatrics. 2015 Oct; 136 Suppl 1:S60-81. View abstract
  2. Buie T. Potential Etiologic Factors of Microbiome Disruption in Autism. Clin Ther. 2015 May 01; 37(5):976-83. View abstract
  3. Buie T. The relationship of autism and gluten. Clin Ther. 2013 May; 35(5):578-83. View abstract
  4. Williams BL, Hornig M, Buie T, Bauman ML, Cho Paik M, Wick I, Bennett A, Jabado O, Hirschberg DL, Lipkin WI. Impaired carbohydrate digestion and transport and mucosal dysbiosis in the intestines of children with autism and gastrointestinal disturbances. PLoS One. 2011; 6(9):e24585. View abstract
  5. Kushak RI, Lauwers GY, Winter HS, Buie TM. Intestinal disaccharidase activity in patients with autism: effect of age, gender, and intestinal inflammation. Autism. 2011 May; 15(3):285-94. View abstract
  6. Buie T, Fuchs GJ, Furuta GT, Kooros K, Levy J, Lewis JD, Wershil BK, Winter H. Recommendations for evaluation and treatment of common gastrointestinal problems in children with ASDs. Pediatrics. 2010 Jan; 125 Suppl 1:S19-29. View abstract
  7. Buie T, Campbell DB, Fuchs GJ, Furuta GT, Levy J, Vandewater J, Whitaker AH, Atkins D, Bauman ML, Beaudet AL, Carr EG, Gershon MD, Hyman SL, Jirapinyo P, Jyonouchi H, Kooros K, Kushak R, Levitt P, Levy SE, Lewis JD, Murray KF, Natowicz MR, Sabra A, Wershil BK, Weston SC, Zeltzer L, Winter H. Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report. Pediatrics. 2010 Jan; 125 Suppl 1:S1-18. View abstract
  8. Campbell DB, Buie TM, Winter H, Bauman M, Sutcliffe JS, Perrin JM, Levitt P. Distinct genetic risk based on association of MET in families with co-occurring autism and gastrointestinal conditions. Pediatrics. 2009 Mar; 123(3):1018-24. View abstract
  9. Hornig M, Briese T, Buie T, Bauman ML, Lauwers G, Siemetzki U, Hummel K, Rota PA, Bellini WJ, O'Leary JJ, Sheils O, Alden E, Pickering L, Lipkin WI. Lack of association between measles virus vaccine and autism with enteropathy: a case-control study. PLoS One. 2008 Sep 04; 3(9):e3140. View abstract
  10. Nanthakumar NN, Young C, Ko JS, Meng D, Chen J, Buie T, Walker WA. Glucocorticoid responsiveness in developing human intestine: possible role in prevention of necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2005 Jan; 288(1):G85-92. View abstract
  11. Chitkara DK, Nurko S, Shoffner JM, Buie T, Flores A. Abnormalities in gastrointestinal motility are associated with diseases of oxidative phosphorylation in children. Am J Gastroenterol. 2003 Apr; 98(4):871-7. View abstract
  12. Biller JA, Katz AJ, Flores AF, Buie TM, Gorbach SL. Treatment of recurrent Clostridium difficile colitis with Lactobacillus GG. J Pediatr Gastroenterol Nutr. 1995 Aug; 21(2):224-6. View abstract
  13. Di Lorenzo C, Flores AF, Buie T, Hyman PE. Intestinal motility and jejunal feeding in children with chronic intestinal pseudo-obstruction. Gastroenterology. 1995 May; 108(5):1379-85. View abstract
  14. Gryboski JD, Buie T. Immunoglobulin studies in children with inflammatory bowel disease. Ann Allergy. 1994 Jun; 72(6):525-7. View abstract
  15. Irons M, Elias ER, Tint GS, Salen G, Frieden R, Buie TM, Ampola M. Abnormal cholesterol metabolism in the Smith-Lemli-Opitz syndrome: report of clinical and biochemical findings in four patients and treatment in one patient. Am J Med Genet. 1994 May 01; 50(4):347-52. View abstract
  16. Biller JA, Flores A, Buie T, Mazor S, Katz AJ. Tetracycline-induced esophagitis in adolescent patients. J Pediatr. 1992 Jan; 120(1):144-5. View abstract